Pathology
Embryofetal-Perinatal Post Mortem Examination

Cytogenetics - Provides analysis of following samples using routine and special banding techniques including metaphase and interphase flourescence-in-situ-hybridization (FISH)
Blood
Bone Marrow
Chorionic Villi
Amniotic Fluid
Solid Tissue
Percutaneous Umbilic Cord Sample
Tumors

Molecular Genetics Employs PCR and Southern blot techniques to detect the following inherited diseases and oncological conditions.
Fragile X Syndrome
Sickle Cell Anemia
Congenital Adrenal Hyperplasia
Muscular Dystrophy
Hemophilia A
Coagulation Factor V
Von-Hippel Lindau Disease
Hemochromatosis
Spinal Bulbar Muscular Atrophy
Leber's Hereditary Optic Neuropathy
NARP Syndrome and Leigh's Disease
Melas
MERFF
Kearns-Sayre
IG & TCR gene analysis for Leukemia/Lymphoma
IG & TCR gene analysis for Minimal Residual Disease
N-Myc amplification for Neuroblastoma
Polymorphism analysis for Bone Marrow Transplant
MLL Rearrangement
Myc Rearrangement
BCR Rearrangement

BioChemical Genetics
Amino Acids, quantitative (plasma or CSF or urine)
Amino Acids, qualitative (urine)
Carbohydrates, Profile
Galactose-1 -Phosphate Uridyl Transferase (GAL-1 -PUT or GALT), quantitative
GALT PCR
Homogentisic Acid, qualitative, (urine)
Monosacchrides, qualitative
Mucopolysaccharides Profile, identification and quantitative
Oligosaccharides, qualitative
O-Phenylhydroxyacetic Acid 0PHAA, qualitative
Phenylalanine, quantitative
Pipecolic Acid, quantitative
Red Blood Cell Enzymes - Glycolytic

Tyrosine, quantitative, flurometric
Uroporphyrinogen-I-Synthase, quantitative

Molecular Pathology
Chlamydia PCR CMV by PCR Enterovirus by PCR

Other
FK506 - Tacrolimus

Hypercoagulable State - this battery of tests screens for a primary hypercoagulable disorder in patients with recurrent thromboembolism:
· APC resistance / Factor V Leiden
· Lupus anticoagulant
· Antithrombin
· Anticardiolipin antibodies
· Protein C
· Homocysteine
· Protein S
· Prothrombin gene mutation

Von Willebrand's Screening - the most common of the hereditary defects of coagulation includes:
· Bleeding time
· Factor VIII Assay
· Ristocetin cofactor
· von Willebrand factor antigen
· Platelet aggregation testing including ristocetin

Anticoagulant Drug Monitoring - special assays to assist in anticoagulant drug monitoring
· Heparin Assay
· Low molecular weight heparin
· Factor X chromogenic assay - (monitor warfarin therapy in patients with established lupus anticoagulant)

Coagulation Factors:
· Fibrinogen
· Factor IX Activity
· Factor II Activity
· Factor X Activity
· Factor V Activity.
· Factor XI Activity
· Factor VII Activity
· Factor XII Activity
· Factor VIII Activity
· Factor XIII (qualitative)

Platelet Testing:
· Platelet Aggregation (ADP, Collagen, Arachidonic Acid, Ristocetin,Epinephrin
· Platelet Antibody (IgG) Direct)
· Heparin Induced Platelet Antibody
· Bleeding Time

Molecular Diagnostic Testing by PCR*

Infectious Disease Tests
Hepatitis C Virus (HCV), qualitative
Cytomegalovirus (CMV), qualitative
HIV-1 viral load, quantitative, ultrasensitive
Chlamydia trachomatis
Neisseria gonorrhoeae

Genetic Variant Tests
Factor V Leiden
Hemochromatosis
Prothrombin
PCR is performed pursuant to a license agreement with Roche Molecular Systems, Inc.

Flow Cytometry Testing

HIV CD4 - used to monitor CD4 counts in HIV infected patients.

Immune Deficiency Panel - designed to monitor T helper and suppressor abnormalities in
patients infected with HIV. Includes CD3, CD4, CD8 and CD4/8 ratio.

Transplant Panel - analysis of T cell and B cell populations. Includes CD2, CD3, CD4, CD8
CD19 and CD4/8 ratio.

Immune Function Panel - provides extensive analysis of T cell, B cell and natural killer cell populations.
Designed to investigate cellular immune status in autoimmune and primary immunodeficiency diseases.
Inclued CD2, CD3, CD4, CD8, CD19 and CD4/8 ratio; also includes CD5, CD56 and HLA-DR.

Leukemia/Lymphoma Panels - a comprehensive, customized selection of reagents for
immunophenotyping and classifying acute leukemia, chronic lymphoid leukemia and lymphoma.

Fetal Maturity Analysis
Fetal Lung Panel, Amniotic Fluid
Lecithin-Sphingomyelin (L/S) Ratio
Phosphatidylinosital (PI)
Phosphatidylglycerol (PG)
Precipitable Lecithin (PPLD)

Maternal Serum Screening
Maternal Serum Screening Program
Alpha-fetoprotein (AFP)
Estriol (unconjugated)
Human Chorionic Gonadotropins

Fetal Fibrinectin Test

Anatomic Pathology
Cytopathology - Traditional and ThinPrep Preparations
Dermatopathology
Liver Pathology
Renal Pathology
Breast Tumor Markers- Estrogen Progesterone Receptor Assays, DNA Ploidy,
-KI 67 and Her-2-Neu
Brain, Muscle and Nerve Pathology
Electron Microscopy
Immunofluorescence
Immunohistochemical Stains, comprehensive selection